bacterial lipopolysaccharides pretreatment protects

نویسندگان

e abdella

چکیده

abstract   the mutagenic and immunosuppressory effects of cyclophosphamide (cyp) are still the primary limitation to wider application for treating a variety of human malignancies. on the one hand, cyp treatment predisposes transplant recipients and cancer patients to risk of bacterial, fungal, and viral infections, in the other word the, lipopolysaccharide (lps), an endotoxin found in cell walls of gram- negative bacteria, has been shown to play a significant role in development a of multiple immune system responses and can cause a fatal pathological effect. the present investigation is focused on immunization of mice with the endotoxin lps prior to cyp treatment, in an attempt to reduce mutagenicity and immunosuppressory effects caused by cyp. the in vivo anti-cytotoxicity and anti- mutagenicity of the inflammatory agents of bacterial lipopolysaccharides (lps) isolated from aeromonas hydrophila was evaluated by bone marrow chromosomal aberrations assay, differential white blood cells (wbcs) count and respiratory burst enzymatic assays for phagocytosis in mice exposed to cyp. the data presented in this article indicates that, treatment with low dose of bacterial lps once a week for four weeks at a dose of 0.2 ml of lps suspension (50 µg/kg mice/week), was non- cytotoxic and un-mutagenic to the animal cells. however, pretreatment with low dose of bacterial lps significantly increase cellular resistance to the mutagenic and immunosuppressory effects of cyp. in conclusion, this immunization protocol suggests that immunization of mice by lps prior to cyp treatment may induce a number of adaptive antimutagenic and immune response molecular mechanisms.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

LIPID A and BACTERIAL LIPOPOLYSACCHARIDES

1. Structure and Occurrence The envelope of Gram-negative bacteria, including those of human pathogens such as Escherichia coli and Salmonella enterica, is composed of two distinct lipid membranes: an inner membrane, consisting of glycerophospholipids, and a highly distinctive outer membrane. The latter is an asymmetric bilayer, the outer leaflet of which in most species consists predominantly ...

متن کامل

Human Nod1 confers responsiveness to bacterial lipopolysaccharides.

The immune response to microbial pathogens is initiated by recognition of specific pathogen components by host cells both at the cell surface and in the cytosol. While the response triggered by pathogen products at the surface of immune cells is well characterized, that initiated in the cytosol is poorly understood. Nod1 is a member of a growing family of intracellular proteins with structural ...

متن کامل

Melatonin pretreatment protects against focal cerebral

View MELATONIN PRETREATMENT PROTECTS AGAINST FOCAL CEREBRAL ISCHEMIA IN THE RAT. H.T.S. Ho; Z. Pei; S.F. Pang; R.T.F. Cheung 1. Medicine, The University of Hong Kong, Pokfulam, Hong Kong 2. Physiology, The University of Hong Kong, Pokfulam, Hong Kong Melatonin (MT) possesses many properties of an ideal neuroprotectant. In this study, the neuroprotective effects of exogenous MT were tested in a ...

متن کامل

Plant Proanthocyanidins Bind to and Neutralize Bacterial Lipopolysaccharides

Proanthocyanidins (PACs) are naturally occurring polymers derived from higher plants and they have recently been associated with several potential positive health benefits such as antibacterial, chemotherapeutic, and anti-atherosclerotic activities. Here we report on the binding of PACs from cranberries, tea, and grapes to lipopolysaccharide (LPS), a major component of the outer membrane of Gra...

متن کامل

Genetic Control of Responses to Bacterial Lipopolysaccharides in Mice

In vivo immune responses and in vitro mitogenic responses to bacterial lipopolysaccharides (LPS) have been compared in strains of C3H mice. C3H/HeJ spleen cultures did not support mitogenic responses to LPS and in vivo these mice produce low IgM responses to LPS. On the basis of these two responses, C3H/HeJ mice have been termed low LPS responders. All other strains of C3H mice tested (C3HeB/Fe...

متن کامل

Induction of human granulocyte chemiluminescence by bacterial lipopolysaccharides.

Bacterial lipopolysaccharides (LPS) have been reported to influence the oxidative response of human polymorphonuclear leukocytes (PMN). However, results sometimes conflict. In the present study, we demonstrated that activation of human PMN by LPS depends on the class (smooth [S] or rough [R]) to which the LPS belongs. Lucigenin-dependent chemiluminescence was used to assay oxygen radical produc...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of cancer prevention

جلد ۱، شماره ۴، صفحات ۱۵۵-۱۶۵

کلمات کلیدی
[ ' l i p o p o l y s a c c h a r i d e ' , ' c y c l o p h o s p h a m i d e ' , ' a n t i m u t a g e n i c ' , ' i m m u n e r e s p o n s e r e f e r e n c e s 1 . t h o m s o n a b ' , ' c r i t c h l e y h o ' , ' k e l n a r c ' , ' e t a l . l a t e r e p r o d u c t i v e s e q u e l a e f o l l o w i n g t r e a t m e n t o f c h i l d h o o d c a n c e r a n d o p t i o n s f o r f e r t i l i t y p r e s e r v a t i o n . b e s t p r a c t . r e s c l i n e n d o c r i n o l m e t a b . 2 0 0 2 ' , 1 6 , 3 1 1 , ' 3 4 . 2 . c o l v i n o m . a n o v e r v i e w o f c y c l o p h o s p h a m i d e d e v e l o p m e n t a n d c l i n i c a l a p p l i c a t i o n s . c u r r p h a r m . 1 9 9 9 ' , 5 , 5 5 5 , ' 6 0 . 3 . t r i p h a t y d n ' , ' j e n a g b . a s t a x a n t h i n i n h i b i t s c y t o t o x i c a n d g e n o t o x i c e f f e c t s o f c y c l o p h o s p h a m i d e i n m i c e g e r m c e l l s . t o x i c o l . 2 0 0 8 ' , ' 2 4 8 ( 2 ' , ' 3 ) ' , 9 6 , ' 1 0 3 . 4 . j o r g e i ' , ' g o n z a l e z b ' , ' a m a d e u c ' , ' e t a l . t h e m u t a g e n i c p o t e n t i a l o f t h e f u r y l e t h y l e n e d e r i v a t i v e 2 ' , ' f u r y l ' , 1 , ' n i t r o e t h e n e i n t h e m o u s e b o n e m a r r o w m i c r o n u c l e u s t e s t . t o x i c o l s c i e n . 2 0 0 3 ' , 7 2 , 3 5 9 , ' 6 2 . 5 . m o k c c ' , ' h o c t ' , ' c h a n k w ' , ' e t a l . o u t c o m e a n d p r o g n o s t i c i n d i c a t o r s o f d i f f u s e p r o l i f e r a t i v e l u p u s g l o m e r u l o n e p h r i t i s t r e a t e d w i t h s e q u e n t i a l o r a l c y c l o p h o s p h a m i d e a n d a z a t h i o p r i n e . a r t h r i t i s r h e u m . 2 0 0 2 ' , 4 6 , 1 0 0 3 , ' 1 3 . 6 . w e i n e r h l ' , ' c o h e n ' , ' j . a . t r e a t m e n t o f m u l t i p l e s c l e r o s i s w i t h c y c l o p h o s p h a m i d e ' , ' c r i t i c a l r e v i e w o f c l i n i c a l a n d i m m u n o l o g i c e f f e c t s . m u l t s c l e r . 2 0 0 2 ' , 8 , 1 4 2 , ' 5 4 . 7 . c a i y ' , ' w u m h ' , ' l u d e m a n s m ' , ' e t a l . r o l e o f o 6 ' , ' a l k y l g u a n i n e ' , ' d n a a l k y l t r a n s f e r a s e i n p r o t e c t i n g a g a i n s t c y c l o p h o s p h a m i d e ' , ' i n d u c e d t o x i c i t y a n d m u t a g e n i c i t y . c a n c e r r e s e a r c h . 1 9 9 9 ' , 5 9 , 3 0 5 9 , ' 6 3 . 8 . a s o u n ' , ' s u z u s h i m a h ' , ' n i s h i m u r a s ' , ' e t a l . l o n g ' , ' t e r m r e m i s s i o n i n a n e l d e r l y p a t i e n t w i t h m a n t l e c e l l l e u k e m i a t r e a t e d w i t h l o w ' , ' d o s e c y c l o p h o s p h a m i d e . a m j h e m a t o l . 2 0 0 0 ' , 6 3 , ' 3 5 7 . 9 . s a n t o s o u s s o m ' , ' d i v a n g a h i m ' , ' z g a n i a c s a . r e d u c e d t i s s u e m a c r o p h a g e p o p u l a t i o n i n t h e l u n g b y a n t i c a n c e r a g e n t c y c l o p h o s p h a m i d e ' , ' r e s t o r a t i o n b y l o c a l g r a n u l o c y t e m a c r o p h a g e ' , ' c o l o n y ' , ' s t i m u l a t i n g f a c t o r g e n e t r a n s f e r . b l o o d . 2 0 0 2 ' , 9 9 , ' 1 2 4 6 5 2 . 1 0 . v o g e l s m t ' , ' h e r m s e n c c ' , ' h u y s h l ' , ' e t a l . r o l e s o f t u m o r n e c r o s i s f a c t o r a l p h a ' , ' g r a n u l o c y t e m a c r o p h a g e c o l o n y ' , ' s t i m u l a t i n g f a c t o r ' , ' p l a t e l e t ' , ' a c t i v a t i n g f a c t o r ' , ' a n d x a 0 x a 0 v o l 1 ' , ' n o 4 ' , ' a u t u m n 2 0 0 8 1 6 3 e h a b a b d e l l a x a 0 x a 0 x a 0 a r a c h i d o n i c a c i d m e t a b o l i t e s i n i n t e r l e u k i n ' , 1 , ' i n d u c e d r e s i s t a n c e t o i n f e c t i o n i n n e u t r o p e n i c m i c e . i n f e c t i m m u n . 1 9 9 4 ' , 6 2 , 2 0 6 5 , ' 7 0 . 1 1 . m o r a t o e f ' , ' g e r b a s e ' , ' d e l i m a m ' , ' g o r c z y n s k i r m . c o n d i t i o n e d i m m u n o s u p p r e s s i o n i n o r a l l y i m m u n i z e d m i c e . b r a i n b e h a v i m m u n 1 9 9 6 ' , 1 0 , ' 4 4 5 4 . 1 2 . l e v e s q u e j p ' , ' h e n d y j ' , ' t a k a m a t s u y ' , ' e t a l . m o b i l i z a t i o n b y e i t h e r c y c l o p h o s p h a m i d e o r g r a n u l o c y t e c o l o n y ' , ' s t i m u l a t i n g f a c t o r t r a n s f o r m s t h e b o n e m a r r o w i n t o a h i g h l y p r o t e o l y t i c e n v i r o n m e n t . e x p h e m a t o l . 2 0 0 2 ' , 3 0 , 4 4 0 , ' 9 . 1 3 . l e v e s q u e j p ' , ' h e n d y j ' , ' t a k a m a t s u y ' , ' e t a l . d i s r u p t i o n o f t h e c x c r 4 / c x c l 1 2 c h e m o t a c t i c i n t e r a c t i o n d u r i n g h e m a t o p o i e t i c s t e m c e l l m o b i l i z a t i o n i n d u c e d b y g c s f o r c y c l o p h o s p h a m i d e . j c l i n i n v e s t . 2 0 0 3 ' , 1 1 1 , 1 8 7 , ' 9 6 1 4 . m u h h ' , ' p e n n y r ' , ' s e w e l l w a . i n t e r l e u k i n ' , ' 5 i s n e c e s s a r y f o r e o s i n o p h i l i a i n d u c e d b y c y c l o p h o s p h a m i d e i n i m m u n i z e d m i c e . i m m u n o l . 1 9 9 3 ' , 7 9 , ' 4 5 2 8 . 1 5 . b u i s m a n a m ' , ' v a n z w e t t l ' , ' l a n g e r m a n s j a ' , ' e t a l . d i f f e r e n t e f f e c t o f g r a n u l o c y t e c o l o n y ' , ' s t i m u l a t i n g f a c t o r o r b a c t e r i a l i n f e c t i o n o n b o n e ' , ' m a r r o w c e l l s o f c y c l o p h o s p h a m i d e ' , ' t r e a t e d o r i r r a d i a t e d m i c e . i m m u n o l . 1 9 9 9 ' , 9 7 , 6 0 1 , ' 1 0 . 1 6 . a n d e r s o n d ' , ' b i s h o p j b ' , ' g a r n e r r c ' , ' e t a l . c y c l o p h o s p h a m i d e . r e v i e w o f i t s m u t a g e n i c i t y f o r a n a s s e s s m e n t o f p o t e n t i a l g e r m c e l l r i s k s . m u t r e s . 1 9 9 5 ' , 3 3 0 , 1 1 5 , ' 8 1 . 1 7 . c h u n g f ' , ' y o u n g r ' , ' h e c h t s s . f o r m a t i o n o f c y c l i c 1 ' , ' n 2 ' , ' p r o p a n o d e o x y g u a n o s i n e a d d u c t s i n d n a u p o n r e a c t i o n w i t h a c r o l e i n o r c r o t o n a l d e h y d e . c a n c e r r e s . 1 9 8 4 ' , 4 4 , 9 9 0 , ' 5 . 1 8 . j a c o b s o n ' , ' k r a m d ' , ' a l b e r t i n i r j ' , ' b r a n d a r . m e a s u r e m e n t o f c h r o m o s o m a l a b e r r a t i o n s i s t e r c h r o m a t i d e x c h a n g e ' , ' h p r t m u t a t i o n a n d d n a a d d u c t s i n p e r i p h e r a l l y m p h o c y t e s o f h u m a n p o p u l a t i o n s a t i n c r e a s e d r i s k f o r c a n c e r . e n v i r o n h e a l t h p e r s p e c t . 1 9 9 3 ' , 1 0 1 , 1 2 1 , ' 5 . 1 9 . z a k s ' , ' z i l b e r m a n m ' , ' s a l k o w s k i c a ' , ' e l s a s s e r t ' , ' e t a l . i n d u c t i o n o f a d r e n o m e d u l l i n m r n a a n d p r o t e i n b y l i p o p o l y s a c c h a r i d e a n d p a c l i t a x e l ( t a x o l ) i n m u r i n e m a c r o p h a g e s . i n f e c t i o n i m m u n i t y . 1 9 9 8 ' , ' 6 6 ( 1 0 ) ' , 4 6 6 9 , ' 7 5 . 2 0 . y o n g j n ' , ' s a n g b h ' , ' j o n g s k ' , ' e t a l . l a c t o f e r r i n w o r k s a s a n e w l p s ' , ' b i n d i n g p r o t e i n i n i n f l a m m a t o r y a c t i v a t i o n o f m a c r o p h a g e s . i n t i m m u n o p h a r m a c o l . 2 0 0 4 ' , 4 , 1 1 8 7 , ' 9 9 . 2 1 . r o b e r t s m ' , ' a l a n w v . s h i e l d a s s i g n a l ' , ' l i p o p o l y s a c c h a r i d e s a n d t h e e v o l u t i o n o f i m m u n i t y t o g r a m ' , ' n e g a t i v e b a c t e r i a . p l o s p a t h o g . 2 0 0 6 ' , ' 2 ( 6 ) ' , ' 6 7 . 2 2 . h e i n e h ' , ' r i e t s c h e l e t ' , ' u l m e r a j . t h e b i o l o g y o f e n d o t o x i n . m o l b i o t e c h n o l . 1 9 9 9 ' , ' 1 9 ( 3 ) ' , ' 2 7 9 9 6 . 2 3 . v a n ' , ' d e u s e n j b ' , ' s h a h m h ' , ' b e c k n e l l b ' , ' e t a l . s t a t ' , 1 , ' m e d i a t e d r e p r e s s i o n o f m o n o c y t e i n t e r l e u k i n ' , ' 1 0 g e n e e x p r e s s i o n i n v i v o . e u r j i m m u n o l . 2 0 0 6 ' , ' 3 6 ( 3 ) ' , 6 2 3 , ' 3 0 . 2 4 . p a n d u r a n g a r a o v l ' , ' b l a z i n a s ' , ' b h e r j e r . c a d m i u m c h l o r i d e s t r o n g l y e n h a n c e s c y c l o p h o s p h a m i d e ' , ' i n d u c e d c h r o m o s o m e a b e r r a t i o n s i n m o u s e b o n e m a r r o w c e l l s . e n v i r o n m o l e c u l m u t a g e n e s i s . 1 9 9 7 ' , 2 9 , 1 9 , ' 2 3 . 2 5 . s c h i l l w b ' , ' p h e l p s s r ' , ' p y l e s w . m u l t i l o c u s e l e c t r o p h o r e t i c a s s e s s m e n t o f y e r s i n i a r u c k e r i . a p p . e n v i r o n m i c r o b i o l . 1 9 8 4 ' , 4 9 , 9 7 5 , ' 9 . x a 0 2 6 . a u s t i n b ' , ' a u s t i n d a . m e t h o d s f o r t h e m i c r o b i o l o g i c a l e x a m i n a t i o n o f f i s h a n d s h e l l f i s h . e l l i s h a r w o o d l i m i t e d ( p u b l i s h e r ' , ' c h i c h e s t e r ) . 1 9 8 9 . 2 7 . w e s t p h a l o ' , ' j a n n k . b a c t e r i a l l i p o p o l y s a c c h a r i d e s ' , ' e x t r a c t i o n w i t h p h e n o l e ' , ' w a t e r a n d f u r t h e r a p p l i c a t i o n s o f t h e p r o c e d u r e . m e t h o d s c a r b o h y d r . c h e m . 1 9 6 5 ' , 5 , 8 3 , ' 9 1 . 2 8 . 2 8 . d a c i e s j ' , ' l e w i s s m . p r a c t i c a l h a e m a t o l o g y . 7 t h e d i t i o n . c h u r c h i l l l i v i n g s t o n e . 1 9 9 1 . 2 9 . s i w i c k i a k . i m m u n o s t i m u l a t i n g i n f l u e n c e o f l e v a m i s o l e o n n o n s p e c i f i c i m m u n i t y i n c a r p ( c y p r i n u s c a r p i o ) . d e v c o m p i m m u n o l . 1 9 8 9 ' , ' 1 3 ( 1 ) ' , 8 7 , ' 9 1 . 3 0 . 3 0 . c o h e n g ' , ' d e m b i e c d ' , ' m a r c u s j . m e a s u r e m e n t o f c a t a l a s e a c t i v i t y i n t i s s u e e x t r a c t s . a n a l b i o c h e m . 1 9 7 0 ' , 3 4 , 3 0 , ' 3 8 . 3 1 . s i n h a a k . c o l o r i m e t e r i c a s s a y o f c a t a l a s e . a n a l . b i o c h e m . 1 9 7 3 ' , 4 7 , 3 8 9 , ' 9 5 . 3 2 . k a r m ' , ' m i s h r a d . c a t a l a s e ' , ' p e r o x i d a s e a n d p o l y p h e n o l o x i d a s e a c t i v i t i e s d u r i n g r i c e l e a f s e n e s c e n c e . p l a n t p h y s i o l o g y . 1 9 7 6 ' , 5 7 , 3 1 5 , ' 1 9 . 3 3 . j o s e p h p ' , ' m u r t h y k r ' , ' n e l s o n j l ' , ' e t a l . p e r o x i d a s e ' , ' a n o v e l p a t h w a y f o r c h e m i c a l o x i d a t i o n i n h u m a n t e r m p l a c e n t a . p l a c e n t a . 1 9 9 2 ' , ' 1 3 ( 6 ) ' , 5 4 5 , ' 5 4 . 3 4 . z o u g l ' , ' g u i x f ' , ' z h o n g x l ' , ' e t a l . i m p r o v e m e n t s i n p y r o g a l l o l a u t o ' , ' o x i d a t i o n m e t h o d f o r t h e d e t e r m i n a t i o n o f s o d a c t i v i t y . p r o g r e s s i n b i o c h e m i s t r y a n d b i o p h y s i c s . 1 9 8 6 ' , 4 , 7 1 , ' 3 . 3 5 . p r e s t o n r j ' , ' d e a n b j ' , ' g a l l o w a y s ' , ' e t a l . m a m m a l i a n i n v i v o c y t o g e n e t i c a s s a y s ' , ' a n a l y s i s o f c h r o m o s o m a l a b e r r a t i o n s i n b o n e m a r r o w c e l l s . m u t r e s . 1 9 8 7 ' , 1 8 9 , 1 5 7 , ' 6 5 . 3 6 . s h u k l a y ' , ' t a n e j a p . a n t i m u t a g e n i c e f f e c t s o f g a r l i c e x t r a c t o n c h r o m o s o m a l a b e r r a t i o n s . c a n c e r l e t t . 2 0 0 2 ' , 1 7 6 , 3 1 , ' 6 . 3 7 . p c ' , ' s t a t o n e ' , ' w a y a n a l y s i s o f v a r i a n c e p r o c e d u r e . g e o r g i a u n i v . 1 9 9 5 . 3 8 . h a f e n r i c h t e r d g ' , ' r o l a n d c r ' , ' m a n g i n o m j ' , ' e t a l . t h e k u p f f e r c e l l i n e n d o t o x i n t o l e r a n c e ' , ' m e c h a n i s m o f p r o t e c t i o n a g a i n s t l e t h a l e n d o t o x e m i a . s h o c k . 1 9 9 4 ' , 2 , 2 5 1 , ' 6 . 3 9 . f r e u d e n b e r g m a ' , ' g a l a n o s c . i n d u c t i o n o f t o l e r a n c e t o l i p o p o l y s a c c h a r i d e ( l p s ) ' , ' d ' , ' g a l a c t o s a m i n e l e t h a l i t y b y p r e t r e a t m e n t w i t h l p s i s m e d i a t e d b y m a c r o p h a g e s . i n f e c t i m m u n . 1 9 9 8 ' , 5 6 , 1 3 5 2 , ' 7 . 4 0 . a l e x a n d e r h r ' , ' d o h e r t y g m ' , ' b l o c k m i ' , ' e t a l . s i n g l e ' , ' d o s e t u m o r n e c r o s i s f a c t o r p r o t e c t i o n a g a i n s t e n d o t o x i n ' , ' i n d u c e d s h o c k a n d t i s s u e i n j u r y i n r a t s . i n f e c t . i m m u n . 1 9 9 1 ' , 5 9 , 3 8 8 9 , ' 9 4 . 4 1 . l e o n p ' , ' r e d m o n d h p ' , ' s h o u j ' , ' e t a l . i n t e r l e u k i n ' , ' 1 a n d i t s r e l a t i o n s h i p t o e n d o t o x i n t o l e r a n c e . a r c h s u r g . 1 9 9 2 ' , 1 2 7 , 1 4 6 , ' 5 1 . 4 2 . a b d u l ' , ' h a i a ' , ' w e i s s l ' , ' s l a v i n s ' , ' e t a l . i m p r o v e d s u r v i v a l f o l l o w i n g i n d u c t i o n o f g v h d f o l l o w i n g l i p o p o l y s a c c h a r i d e i m m u n i z a t i o n . e x h e m a t o l . 2 0 0 6 ' , 3 4 , ' 5 4 9 5 3 . 4 3 . y o z a b ' , ' l a ' , ' r u e k ' , ' m c c a l l c . m o l e c u l a r m e c h a n i s m s r e s p o n s i b l e f o r e n d o t o x i n t o l e r a n c e . p r o g c l i n b i o l r e s . 1 9 9 8 ' , 3 9 7 , 2 0 9 , ' 1 5 . 4 4 . l i u j ' , ' l o u i s e s ' , ' a n d r e w p ' , ' e t a l . e n d o t o x i n p r e t r e a t m e n t p r o t e c t s a g a i n s t t h e h e p a t o t o x i c i t y o f a c e t a m i n o p h e n a n d c a r b o n t e t r a c h l o r i d e ' , ' r o l e o f c y t o c h r o m e x a 0 p 4 5 0 s u p p r e s s i o n . t o x i c o l o g y . 2 0 0 0 ' , 1 4 7 , 1 6 7 , ' 7 6 . x a 0 x a 0 x a 0 x a 0 i r a n i a n j o u r n a l o f c a n c e r p r e v e n t i o n 1 6 4 b a c t e r i a l l i p o p o l y s a c c h a r i d e s p r e t r e a t m e n t . . . x a 0 x a 0 x a 0 4 5 . g u i d o t d m . e n d o t o x i n p r e t r e a t m e n t i n v i v o i n c r e a s e s t h e m i t o c h o n d r i a l r e s p i r a t o r y c a p a c i t y i n r a t h e p a t o c y t e s . a r c h b i o c h e m b i o p h y s . 1 9 9 8 ' , 3 5 4 , 9 , ' 1 7 . 4 6 . c a l a b r e s e e j ' , ' m e h e n d a l e h m . a r e v i e w o f t h e r o l e o f t i s s u e r e p a i r a s a n a d a p t i v e s t r a t e g y ' , ' w h y l o w d o s e s a r e o f t e n n o n ' , ' t o x i c a n d w h y h i g h d o s e s c a n b e f a t a l . f o o d c h e m t o x i c o l . 1 9 9 6 ' , 3 4 , 3 0 1 , ' 1 1 . 4 7 . l a s k i n d l . s i n u s o i d a l l i n i n g c e l l s a n d h e p a t o t o x i c i t y . t o x i c o l p a t h o l . 1 9 9 6 ' , 2 4 , 1 1 2 , ' 8 . 4 8 . r o t h r a ' , ' h a r k e m a j r ' , ' p e s t k a j p ' , ' e t a l . i s e x p o s u r e t o b a c t e r i a l e n d o t o x i n a d e t e r m i n a n t o f s u s c e p t i b i l i t y t o i n t o x i c a t i o n f r o m x e n o b i o t i c a g e n t s ? . t o x i c o l a p p l p h a r m a c o l . ' , 1 9 9 7 , 1 4 7 , 3 0 0 , ' 3 1 1 . 4 9 . i s h i k a w a m ' , ' t a n n o k ' , ' s a s a k i m ' , ' e t a l . a n t i d o t a l e f f e c t o f l i p o p o l y s a c c h a r i d e a g a i n s t a c e t a m i n o p h e n ' , ' i n d u c e d m o r t a l i t y i n m i c e . p h a r m a c o l t o x i c o l . 1 9 9 0 ' , 6 7 , 3 8 7 , ' 9 1 . 5 0 . c h o r v a t o v i c o v a d ' , ' m a c h o v a e ' , ' s a n d u l a j ' , ' e t a l . p r o t e c t i v e e f f e c t o f t h e y e a s t g l u c o m a n n a n a g a i n s t c y c l o p h o s p h a m i d e ' , ' i n d u c e d m u t a g e n i c i t y . m u t r e s . 1 9 9 9 ' , 4 4 4 , 1 1 7 , ' 2 2 . 5 1 . b a r t o n t s ' , ' w y r o b e k a j ' , ' h i l l f s ' , ' e t a l . n u m e r i c a l c h r o m o s o m a l a b n o r m a l i t i e s i n r a t e p i d i d y m a l s p e r m a t o z o a f o l l o w i n g c h r o n i c c y c l o p h o s p h a m i d e e x p o s u r e . b i o l r e p r o d . 2 0 0 3 ' , 6 9 , 1 1 5 0 , ' 7 . 5 2 . z h a n g q h ' , ' w u c f ' , ' d u a n l ' , ' e t a l . p r o t e c t i v e e f f e c t s x a 0 d n a d a m a g e a n d c e l l a p o p t o s i s i n m i c e . a r c h t o x i c o l . 2 0 0 8 ' , ' 8 2 ( 2 ) ' , 1 1 7 , ' 2 3 . 5 3 . d e ' , ' f l o r a s ' , ' b e n n i c e l l i c ' , ' b a g n a s c o m . g e n o t o x i c i t y o f m e r c u r y c o m p o u n d s . m u t r e s . 1 9 9 4 ' , ' 3 1 7 ( 1 ) ' , 5 7 , ' 7 9 . 5 4 . h e d d l e j a ' , ' m o o d y j a ' , ' t h o m p s o n l u ' , ' e t a l . n e w a p p r o a c h e s t o a n t i m u t a g e n e s i s . j e n v p a t h o l t o x i c o l o n c o l . 1 9 9 9 ' , 1 8 , 9 5 , ' 1 0 1 . 5 5 . s c h u r z f ' , ' s a b a t e r ' , ' v i l a r m ' , ' f i n k ' , ' g r e m m e l s j . m u t a g e n i c i t y o f m e r c u r y c h l o r i d e a n d m e c h a n i s m s o f c e l l u l a r d e f e n c e ' , ' t h e r o l e o f m e t a l ' , ' b i n d i n g p r o t e i n s . m u t a g e n e s i s . 2 0 0 0 ' , ' 1 5 ( 6 ) ' , 5 2 5 , ' 3 0 5 6 . r a o m v ' , ' c h i n o y n j ' , ' s u t h a r m b ' , ' e t a l . r o l e o f a s c o r b i c a c i d o n m e r c u r i c c h l o r i d e ' , ' i n d u c e d g e n o t o x i c i t y i n h u m a n b l o o d c u l t u r e s . t o x i c o l . 2 0 0 1 ' , ' 1 5 ( 6 ) ' , 6 4 9 , ' 5 4 . 5 7 . o h m s ' , ' c h a n g m s ' , ' p a r k w ' , ' e t a l . y u k m i j i h w a n g ' , ' t a n g p r o t e c t s a g a i n s t c y c l o p h o s p h a m i d e ' , ' i n d u c e d r e p r o d u c t i v e t o x i c i t y . r e p r o d t o x i c o l . 2 0 0 7 ' , ' 2 4 ( 3 ' , ' 4 ) ' , 3 6 5 , ' 7 0 . 5 8 . w a r r e n g w ' , ' p o l o y a c s m ' , ' g a r y d s ' , ' e t a l . h e p a t i c c y t o c h r o m e p 4 5 0 e x p r e s s i o n i n t n f ' , ' a ( p 5 5 ' , ' p 7 5 ) k n o c k o u t m i c e f o l l o w i n g e n d o t o x i n a d m i n i s t r a t i o n . j p h a r m a c o l e x p t h e r . 1 9 9 9 ' , 2 8 8 , 9 4 5 , ' 5 0 . 5 9 . a k i r a s ' , ' t a k e d a k ' , ' k a i s h o t . t o l l ' , ' l i k e r e c e p t o r s ' , ' c r i t i c a l p r o t e i n s l i n k i n g i n n a t e a n d a c q u i r e d i m m u n i t y . n a t . i m m u n o l . 2 0 0 1 ' , ' 2 ( 8 ) ' , ' 6 7 5 8 0 . x a 0 o f g i n s e n o s i d e r g ( 3 ) a g a i n s t c y c l o p h o s p h a m i d e ' , ' i n d u c e d ' ]

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023